Endocrine Abstracts

Aim: Netrin is classically recognized as a neural guidance cue that has been involved in various tissues including pancreas development. Because of Netrin’s tissue regenerative, angiogenic, and inflammatory suppression properties it could play a crucial role in the development of insulin resistance and type 2 diabetes. The aim of the current study is to investigate the relation between circulating levels of Netrin-1 and the glucose continuum.Method...

Objective: The beneficial effects of testosterone replacement therapy (TRT) in men with hypogonadism on the body composition and metabolic parametersare well-established, but the intimate mechanisms of these effects are not fully understood. Resistin is a small protein that is involved in the regulation of glucose metabolism and is considered to be key in the development of insulin resistance and to induce proinflammatory effects. We hypothesize that TRT has an impact on the a...

BackgroundBoth obesity and diabetes are associated with chronic low-grade inflammation. IL-18 is a cytokine that stimulates various cell types and has pleiotropic functions. The aim of the present study was to investigate the circulating levels of IL-18 in different stages of glucose dysregulation from obesity through prediabetes to newly diagnosed diabetesMethodsIL-18 levels were determined using a commercia...